Professor David Woolfson

Head of School, School of Pharmacy

Ex Officio Member

Room 0G.009

Pharmacy & MCI, Block 98 Health Sciences

Phone: +44 (0)28 9097 2024

 

Interests


Professor David Woolfson holds the Chair in Pharmaceutics (Drug Delivery).  He is a graduate in Pharmacy from Queen’s and is a registered pharmacist. Prof. Woolfson founded the McClay Research Centre for Pharmaceutical Sciences, from initial concept through to raising of the necessary funding. Starting as a lecturer in pharmaceutical analysis, he was appointed Reader in Pharmaceutical Sciences in 1991 and to the Chair in Pharmaceutics in 1995. He is Head of the School of Pharmacy at Queen’s.

Prof. Woolfson became a member of the British Pharmacopoeia Commission (BPC)  in 1997 and was appointed as Chair of the BPC in 2006. The Commission is responsible under the UK Medicines Act for the annual publication of the British Pharmacopoeia., which sets legally enforceable quality standards for medicinal chemicals, drugs and formulated products. He  has extensive experience of work in the European Pharmacopoeia Commission(EPC) as leader of the UK delegation and  formerly UK Expert on Formulated Medicinal  Products. He is a member of the Editorial Advisory Board of CRC Books Inc. and formerly of the Scientific Advisory Board of the International Partnership for Microbicides. He has published 3 books, approximately 300 scientific publications, holds several patents on drug delivery systems and biomaterials and has given numerous invited conference presentations.

 

Research Statement


Prof. Woolfson’s research interests are in polymeric drug delivery systems for transdermal and intravaginal  applications, bioadhesion and biomaterials.  The emphasis is on facilitated controlled drug delivery through challenging polymeric systems, where physicochemical aspects (drug molecular size,  solubility or stability, polymer system tortuosity and relative hydrophobicity) present difficulties to efficient drug release. The current focus is on novel polymeric systems for transdermal delivery, vaginal delivery of HIV microbicides and the development of vaginally deliveryed HIV mucosal vaccines. Key achievements include the invention of the marketed percutaneous local anaesthetic product  Ametop, and contributions to the development of several other pharmaceuticals, including the vaginal ring HRT product Femring. The research programmes are funded from a range of sources including UK Research Councils, major charities such as the Bill and Melinda Gates Foundation and the Wellcome Trust, the International Partnership for Microbicides and other charities for the prevention of HIV, and the Pharmaceutical Industry. Prof. Woolfson’s career research grants to date total £17M.



 

Publications
Chapter(s)
Title Book Title Year
Self-lubricating catheter materials Biomaterials and tissue engineering in urology 2009
Intravaginal drug delivery technologies Modified-Release Drug Delivery Technology, 2nd.  edition 2008
Vagina and Uterus as Drug Absorbing Organs Enhancement in Drug Delivery 2007
Bioadhesive Drug Delivery Systems Polymeric Biomaterials, 2nd. edn. 2002
Journal(s)
Title Journal Name Year
Sustained release of proteins from a modified vaginal ring device European Journal of Pharmaceutics and Biopharmaceutics Vol XXX (XXX-XXX)  DOI 2011
Controlled-release vaginal ring drug delivery systems: a key strategy for the development of effective HIV microbicides Therapeutic Delivery Vol 1 (785-803)  2010
Freeze-dried, mucoadhesive system for vaginal delivery of the HIV microbicide, dapivirine: Optimisation by an artificial neural network International Journal of Pharmaceutics Vol 388 (136-143)  DOI  <input value=“View Abstract” /></td> 2010
. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. Journal of Controlled Release Vol In Press (136-143)  DOI 2010
Hexyl Aminolaevulinate Is a More Effective Topical Photosensitiser Precursor than Methyl Aminolaevulinate and 5-Aminolaevulinic Acids When Applied in Equimolar Doses Journal of Pharmaceutical Sciences Vol 99 (3486-3498)  DOI  <input value=“View Abstract” /></td> 2010
Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses. Vaccine Vol 27(48) (6791-6798)  DOI 2009
Characterization of the Rheological, Mucoadhesive,  and Drug Release Properties of Highly Structured Gel Platforms for Intravaginal Drug Delivery Biomacromolecules Vol 10 (2427-2435)  DOI  <input value=“View Abstract” /></td> 2009