Professor Michael Shields

Professor of Child Health, Respiratory Medicine Research Cluster, School of Medicine, Dentistry and Biomedical Sciences

Room 03.022

H.S.N.B. Block 10 Health Sciences Building

97 Lisburn Road

Phone: +44 (0)28 9097 2673

Interests


My research interests include:

1] studying the underlying airways inflammation in childhood respiratory disorders including bronchiolitis, wheezing (asthma phenotypes) and problem coughing.

2] non-invasive monitoring of airways inflammation in asthma children

3] using modern technology for  rapid point of care testing of respiratory and serious bacterial infections in children





Teaching


Undergraduate

1] I run a Student Selected Component module in 2nd year undergraduate Medicine course “Ethical issues in Paediatrics”. Teaching in this is by way of case discussions and debates.

2] I teach in 3 other SSCs (Pain in children, neonatal cardiorespiratory transition systems, sleep disordered breathing in children)

3] I teach and assess students in the 4th year Child Health module.

I chair the Phase 4 Quality Assurance Committee

Postgraduate

1] I was the N Ireland Paediatric training director and RCPCH Regional advisor until 2 years ago

2] I am on the national Respiratory Paediatrics training committee (CSAC)

 





Research Statement


My research interests include:

1] studying the underlying airways inflammation in childhood respiratory disorders including bronchiolitis, wheezing (asthma phenotypes) and problem coughing.

2] non-invasive monitoring of airways inflammation in asthma children

3] using modern technology for  rapid point of care testing of respiratory and serious bacterial infections in children





Publications
Chapter(s)
Title Book Title Year
Bronchiolitis Clinical Evidence 2011
Respiratory disease due to extra esophageal reflux in children. Effects, Diagnosis and Management of Extra-esophageal reflux 2010
Respiratory Paediatrics Euro MasterCourse in Paediatrics 2010
Respiratory Paediatrics MRCPCH MasterCourse 2007
Journal(s)
Title Journal Name Year
Extra oesophageal reflux disease in children Alimentary Pharmacology & Therapeutics Vol 33 (suppl s1) (58-65)  2011
Bronchiolitis Clinical Evidence Vol - (—-)  DOI  <input value=“View Abstract” /></td> 2011
Effects of interleukin-13 on mucociliary differentiation of paediatric asthmatic bronchial cells. Pediatric Research Vol 69 (2) (95-100)  DOI  <input value=“View Abstract” /></td> 2011
Development and clinical validation of a loop mediated isothermal amplification (LAMP) method for the rapid detection of Neisseria meningitidis Diagnostic Microbiology and Infectious Disease Vol 69 (2) (137-144)  DOI  <input value=“View Abstract” /></td> 2011
High concentrations of pepsin in bronchoalveolar lavage from children with cystic fibrosis are associated with high interleukin-8 Thorax Vol 66 (2) (140-143)  DOI  <input value=“View Abstract” /></td> 2011
Molecular testing of respiratory swabs aids early recognition of meningococcal disease in children. Diagnostic Microbiology and Infectious Disease Vol -  (—-)  DOI 2011
A20 regulation of NF-kB: perspectives for inflammatory lung disease American Journal Respiratory Cell and Molecular Biology Vol - (—-)  2011
Peanut allergy and allergic airways inflammation. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Vol 21 (1107-1113)  DOI  <input value=“View Abstract” /></td> 2010
Is there a role for intermittent use of long acting beta 2 agonists in childhood asthma? Pediatric Health Vol 4 (3) (287-293)  2010
Does airways inflammation pre-exist before late onset wheeze in children? Pediatric Allergy & Immunology Vol 21 (7)  (1002-1007)  DOI  <input value=“View Abstract” /></td> 2010
A 3-D well differentiated model of pediatric bronchial epithelium demonstrates unstimulated morphological differences between asthmatic and nonasthmatic cells Pediatric Research Vol 67 (17-22)  DOI  <input value=“View Abstract” /></td> 2010
Rapid diagnosis of meningococcal disease Expert Reviews Anti Infective Therapy Vol 8 (12)  (1321-1323)  2010
A/H1N1 pandemic: misdiagnosis in the time of meningitis BMJ (Clinical research ed.) Vol 339 (3423-3423)  2009
Pepsin measured in induced sputum - a test for pulmonary aspiration in children? J Pediatr Surg Vol 44 (10) (1938-1941)  DOI  <input value=“View Abstract” /></td> 2009
Influence of ABCB1 polymorphisms and haplotypes on tacrolimus nephrotoxicity and dosage requirements in children with liver transplant British Journal of Clinical Pharmacology Vol 68(3)  (413-421)  DOI  <input value=“View Abstract” /></td> 2009
Surfactant metabolism dysfunction and childhood interstitial lung disease (chILD) Ulster Medical Journal Vol 78(1) (7-9)  2009
Near-patient testing of respiratory specimens British Medical Journal Vol 336 (1367-1370)  2008
A meta-analysis of the association between Caesarean section and childhood asthma Clinical & Experimental Allergy Vol 38(4)  (629-633)  DOI  <input value=“View Abstract” /></td> 2008
British Thoracic Society Guidelines Recommendations for the assessment and management of cough in children Thorax Vol 63 Suppl 3 (iii1-iii15)  DOI 2008
Should longhaul flights carry antibiotics on board for the treatment of acute bacterial meningitis and meningococcal septicaemia? British Journal of Biomedical Science Vol 65(4)  (202-202)  2008
Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study Pediatric Diabetes Vol 9 (191-196)  DOI  <input value=“View Abstract” /></td> 2008
Respiratory viruses do not trigger meningococcal disease in children Journal of Infection Vol 54(5) (454-458)  2007
Decision making in asthma exacerbation: a clinical judgement analysis Archives of Disease in Childhood Vol 92(8)  (672-677)  2007
BAPS Prize - Pepsin in bronchoalveolar lavage fluid:  a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration Journal of Pediatric Surgery Vol 41 (289-293)  2006
Diagnosing chronic cough in children Thorax Vol 61 (647-648)  2006
Children with stable asthma have reduced airway matrix metalloproteinase-9 and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio Clinical & Experimental Allergy Vol 35(9)  (1168-1174)  DOI  <input value=“View Abstract” /></td> 2005
Employment of broad range 16S rDNA PCR and sequencing in the detection of the aetiological agents of meningitis New Microbiologica Vol 28 (135-143)  2005
A cluster randomised intervention trial of asthma clubs to improve quality of life in primary school children: the School Care and Asthma Management Project (SCAMP) Archives of Disease in Childhood Vol 90 (786-791)  2005
Anesthesia and the child with asthma Pediatric Anesthesia Vol 15 (446-454)  2005
Do major televised events affect pediatric emergency department attendances or delay presentation of surgical conditions? Pediatric emergency care Vol 21 (306-308)  2005
Risk factors for Helicobacter pylori infection in children: an examination of the role played by intrafamilial bed sharing Pediatric Infectious Disease Journal Vol 24 (149-152)  2005
Exhaled nitric oxide in relation to the clinical features of childhood asthma Journal of Asthma Vol 41 (7) (751-757)  DOI 2004
Liquid chromatographic determination including simultaneous “on-cartridge” separation of ranitidine cisapride drug combinations from paediatric plasma samples using an automated solid-phase extraction procedure Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences Vol 806 (263-269)  2004
Monitoring growth in asthmatic children treated with high dose inhaled glucocorticoids does not predict adrenal suppression Archives of Disease in Childhood Vol 89(8)  (713-716)  DOI  <input value=“View Abstract” /></td> 2004
Fast and frugal models of clinical judgement in novice and expert physicians Medical Decision Making Vol 23(4) (293-300)  DOI 2003
Non-bronchoscopic sampling and culture of bronchial epithelial cells in children Clinical & Experimental Allergy Vol 33(9)  (1221-1225)  DOI 2003
T cell cytokine profiles in childhood asthma Thorax Vol 58(4) (311-316)  DOI 2003
Antioxidants and oxidative stress in BAL fluid of atopic asthmatic children Pediatric Research Vol 53 (375-381)  2003
Cough - 2: Chronic cough in children Thorax Vol 58 (998-1003)  2003
A Meta-Analysis of the Association Between Childhood Type 1 Diabetes and Atopic Disease Diabetes Care Vol 26(9) (2568-2574)  DOI 2003
Fast and frugal models of clinical judgement in novice and expert physicians Medical Decision Making Vol 23 (293-300)  2003
Caffeine and exhaled nitric oxide Thorax Vol 58 (281-281)  2003
Smoking, atopy and certain furry pets are major determinants of respiratory symptoms in children: the International Study of Asthma and Allergies in Childhood Study (Ireland) Clinical & Experimental Allergy Vol 33 (96-100)  2003
Home heating and respiratory symptoms among children in Belfast, Northern Ireland Archive of Environmental Health Vol 58 (549-553)  2003
A difficult diagnosis in a pale child Annals of Allergy, Asthma and Immunology Vol 91 (16-19)  2003
Antioxidants and oxidative stress in BAL fluid of atopic asthmatic children Pediatric Research Vol 53 (375-381)  2003
Advances in the management of childhood asthma Current Paediatrics Vol 13 (264-268)  2003
Outgrown asthma does not mean no airways inflammation European Respiratory Journal Vol 19(2) (284-287)  DOI  <input value=“View Abstract” /></td> 2002
Exhaled nitric oxide correlates with airway eosinophils in childhood asthma Thorax Vol 57(5) (383-387)  DOI  <input value=“View Abstract” /></td> 2002
Different sex rations at birth in Europe and North America - Maternal cytomegalovirus seropositivity affects sex determination BMJ Vol 325 (335-335)  2002
Hypoglycemia due to adrenal suppression secondary to high-dose nebulized corticosteroid Pediatric Pulmonology Vol 34 (85-86)  2002
Antioxidants and protein carbonyls in bronchoalveolar lavage fluid of children: normal data Pediatric Research Vol 49(2) (155-161)  DOI 2001
Prevalence and awareness of excess weight in 13 and 14 year olds in Northern Ireland using recent international guidelines Acta Paediatrica Vol 90 (1435-1439)  2001
Acute asthma exacerbations and air pollutants in children living in Belfast, Northern Ireland Archive of Environmental Health Vol 56 (234-241)  2001
The use of hydrophilic lipophilic balanced (HLB)  copolymer SPE cartridges for the extraction of diclofenac from small volume paediatric plasma samples Journal of Pharmaceutical and Biomedical Analysis Vol 25 (871-879)  2001
The use of polymeric solid phase extraction and HPLC analysis for the determination of ranitidine in routine plasma samples obtained from paediatric patients Journal of Pharmacy and Pharmacology Vol 53(9)  (1265-1272)  DOI 2001
Antioxidants and protein carbonyis in bronchoalveolar lavage fluid of children: normal data. Pediatric Research Vol 49 (155-161)  2001
Bronchiolitis: presentation and treatment Proceedings of the Royal College of Physicians Edinburgh Vol 31(3) (218-221)  2001
Bronchoalveolar lavage and tracheal aspirate for assessing airway inflammation in children American Journal of Respiratory Critical Care Medicine Vol 162 (S15-S17)  2000